Achieving Sustainability with Complex Pharmaceutical Challenges: Innovations to Solve Problems

Pharmaceutical development currently relies on quality separation methods from early discovery through to manufacturing. Innovations in column particle packing, ID, length, and connectivity, along with a deeper understanding of key parameters like void volume, flow rate, and temperature, have significantly improved separation quality, including resolution, peak shape, peak width, run time, and signal-to-noise ratio. However, there is a strong need to consider method sustainability when developing reliable separation methods. The current shift toward UHPLC, the wider use of supercritical fluid chromatography (SFC), and a growing interest in miniaturization reflect trends toward chromatographic sustainability. This presentation will explore advancements in miniaturized instrumentation like NMR and LC, 2D HPLC Prep, and SFC in process reaction monitoring. It will also discuss how chromatographers can develop a greater awareness of sustainable separation development using metrics like the analytical method greenness score (AMGS) for strategic advantages, making methods more efficient and sustainable. Progress with methods, applying the best choices will consider newer instrument designs and column technologies over traditional, widely accepted separation methods.