Touch-based Sweat Biosensor Towards Wireless Monitoring of Personal Health and Nutrition

Advances in wearable and noninvasive touch-based sweat biosensor and integration of Self-powered systems are enabling new opportunities for personal health and nutrition monitoring. Here, we present a touch-based sweat biosensing platform designed for real-time, on-site analysis of key nutritional and metabolic biomarkers through natural fingertip perspiration. The system integrates disposable electrochemical sensors with a biofuel cell–powered wireless interface, eliminating the need for external power sources or stimulated sweating.
Two representative sensing modalities were developed: a potentiometric vitamin C sensor embedded in a self-powered Smart Cup and an enzymatic uric acid (UA) biosensor. Smart Cup harvests biochemical energy from natural perspiration oof sweat lactate to operate onboard electronics that detect, process, and wirelessly transmit data vitamin C sensor data. In both studies on-body testing demonstrated dynamic tracking of sweat vitamin C profiles following oral supplementation and uric acid dynamic profiles were tracked by stimulating the uric acid level by high purine rich diet.
This touch-based, battery-free sensing strategy provides a simple, rapid, and noninvasive route for continuous monitoring of nutritional and metabolic biomarkers. The platform highlights the analytical potential of sweat as an accessible biofluid for personalized nutrition and wireless data transmission for continuous health monitoring [1,2].

References:
1. 1. Moonla, C., et al., Touch-based uric acid sweat biosensor towards personal health and nutrition. Biosensors and Bioelectronics, 2025. https://doi.org/10.1016/j.bios.2025.117289
2. Khan, MI., et al., A smart cup for wireless, biofuel-powered, sweat-based vitamin C sensing. Biosensor and Bioelectronics, 2025. https://doi.org/10.1016/j.bios.2025.118100