Oral: Performance of a Next-Generation Inert Capillary Column for Multiresidue GC-MSMS Analysis

The analysis of pesticide residues in complex botanical matrices is often complicated by high levels of co-extracted starches, oils, water, and other naturally occurring compounds that persist even after extensive sample cleanup. Achieving reliable detection and quantitation of pesticides at trace levels demands a chromatographic column with exceptional inertness, resolution, and long-term stability. We present the evaluation of a novel GC capillary column, engineered for outstanding inertness and robustness in GC-MS/MS multiresidue pesticide analysis. Compared to conventional columns, this new design delivers markedly improved peak shape, signal-to-noise, and resolution across a wide variety of challenging botanical matrices, including ashwagandha root, lavender oil, and ginseng powder. A standout feature is its integrated fused silica retention gap at the inlet and fused silica transfer line at the outlet. This innovative construction ensures that retention times remain consistent, even after trimming, allowing for fast and reliable maintenance with no impact on chromatographic performance