Raman Spectroscopy as a versatile analytical tool in biomedical research and clinical diagnostics
Sunday, March 2, 2025 9:50 AM to 10:10 AM · 20 min. (America/New_York)
Room 104B
Organized Session
Bioanalytical & Life Science
Information
When Indian physicist C.V. Raman discovered Raman spectroscopy in 1928, few could have anticipated its vast impact nearly a century later. Today, Raman spectroscopy stands as one of the most crucial analytical tools, with applications spanning science, medicine, and even art history.
In life sciences and medicine, Raman-based technologies are increasingly complementing established methods like fluorescence spectroscopy and microscopy. Raman spectroscopy allows label-free detection of molecular composition and morphology in complex biological samples, such as cells and tissues, with minimal preparation.
This presentation highlights our recent research demonstrating Raman spectroscopy's capability for non-invasive morphochemical characterization across diverse biological samples—ranging from prokaryotic and eukaryotic cells, fungi, and biofilms to tissue sections and entire organs. In this way, Raman studies provide insights and findings on, for example, disease mechanisms for the early diagnosis of diseases, for microbial diagnostics, e.g. for the on-site detection of pathogens, for the visualization of metabolic , defense or chemical communication processes in cells and plant tissue or for an on-site environmental and soil monitoring.
We will show that this surge in the application of Raman spectroscopic bioanalytics has led to advances in both hardware and software, including new Raman fiber probe designs, compact and easy-to-use Raman microscopes that can be used on-site compact and easy-to-use Raman microscopes and most importantly novel data processing techniques that utilize artificial intelligence for the automated evaluation of Raman data sets.
Acknowledgements: Financial support from the EU, Thüringer Ministerium für Wirtschaft, Wissenschaft und Digitale Gesellschaft, Thüringer Aufbaubank, Germany’s Federal Ministry of Education and Research, German Science Foundation, and the Carl-Zeiss Foundation is gratefully acknowledged.
In life sciences and medicine, Raman-based technologies are increasingly complementing established methods like fluorescence spectroscopy and microscopy. Raman spectroscopy allows label-free detection of molecular composition and morphology in complex biological samples, such as cells and tissues, with minimal preparation.
This presentation highlights our recent research demonstrating Raman spectroscopy's capability for non-invasive morphochemical characterization across diverse biological samples—ranging from prokaryotic and eukaryotic cells, fungi, and biofilms to tissue sections and entire organs. In this way, Raman studies provide insights and findings on, for example, disease mechanisms for the early diagnosis of diseases, for microbial diagnostics, e.g. for the on-site detection of pathogens, for the visualization of metabolic , defense or chemical communication processes in cells and plant tissue or for an on-site environmental and soil monitoring.
We will show that this surge in the application of Raman spectroscopic bioanalytics has led to advances in both hardware and software, including new Raman fiber probe designs, compact and easy-to-use Raman microscopes that can be used on-site compact and easy-to-use Raman microscopes and most importantly novel data processing techniques that utilize artificial intelligence for the automated evaluation of Raman data sets.
Acknowledgements: Financial support from the EU, Thüringer Ministerium für Wirtschaft, Wissenschaft und Digitale Gesellschaft, Thüringer Aufbaubank, Germany’s Federal Ministry of Education and Research, German Science Foundation, and the Carl-Zeiss Foundation is gratefully acknowledged.
Session or Presentation
Presentation
Session Number
OC-11-02
Application
Bioanalytical
Methodology
Raman Spectroscopy/SERS
Primary Focus
Application
Morning or Afternoon
Morning
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