Biomolecular Monitoring: From Centralized Lab Assays to Self-Testing and On-Body Monitoring

The detection of nutrients, key disease biomarkers, drug molecules, and toxins in the human body is critically important for healthcare and diagnostics. Our research initially focuses on enhancing the sensitivity of immunosorbent assays (ELISA) through signal amplification strategies leveraging single atom nanozymes (SANs). These SANs exhibit exceptional stability under varying pH and temperature conditions, surpassing natural enzymes in robustness. Their superior catalytic specificity for hydrogen peroxide allows them to replace natural peroxidases, enabling highly sensitive biosensing. Building on this foundation, we have expanded SANs applications to electrochemical platforms for rapid, high-sensitivity detection and lateral-flow immunoassays for portable human biofluid diagnostics. Addressing the increasing demand for continuous, comfortable, and automated health monitoring, we further integrated wearable energy management modules and sensors into wearable microgrid systems. This advancement delivers practical, autonomous, and flexible solutions for self-powered energy management and extended healthcare monitoring.