Skin-Interfaced Wearable Biosensors

The growing interest in personalized medicine is set to transform conventional healthcare, offering new avenues for predictive analytics and tailored treatment approaches. In this talk, I will present our advancements in developing wearable biosensors for non-invasive molecular analysis. These wearables autonomously access and sample body fluids, such as sweat and exhaled breath condensate, continuously monitoring a wide array of analytes—including metabolites, nutrients, hormones, proteins, and drugs—during various daily activities. To enable large-scale, cost-effective manufacturing of these high-performance nanomaterial-based sensors, we leverage techniques such as laser engraving, inkjet printing, and 3D printing. The clinical utility of our wearable systems is assessed through a series of human trials, focusing on precision nutrition, stress response and mental health assessment, chronic disease management, and drug personalization. Our wearable systems' clinical applications are evaluated through human trials in areas like precision nutrition, stress response monitoring, mental health assessment, chronic disease management, and drug personalization. Furthermore, I will explore our efforts in energy harvesting from both the human body and the environment, paving the way for battery-free, wireless biosensing devices. This integration of wearable technologies has the potential to revolutionize personalized healthcare, spanning diagnostics, real-time monitoring, and therapeutic innovations.