Light Scattering Solutions for Vaccine-Related Molecules and Nanoparticles

Accurate and comprehensive characterization of vaccine-related molecules and nanoparticles, from preclinical stage through process development and quality control, are critical to ensure the vaccine product’s safety and efficacy. Nanoparticle antigens, drug delivery vehicles, and excipients used in many vaccines present unique challenges for analyzing quality attributes in their native state. Batch dynamic light scattering (DLS) can provide rapid screening, quantitation, and stability characterization of a wide variety of vaccine macromolecules and nanoparticles. For further in-depth characterization, separation techniques like size-exclusion chromatography (SEC) and field-flow fractionation (FFF) coupled with multi-angle light scattering (MALS) enable quantitation of size-based payload distribution, titer, and other critical quality attributes.