Spectroscopy and the Role it Plays in the Successful Development and Deployment of Modern Biopharmaceutical Medicines

The trend in pharmaceutical research and development has been away from small molecules drugs towards biopharmaceutical based therapeutics. With the outbreak of COVID in 2020 the focus and activity in biopharmaceutical medicine increased rapidly. This led to a whole host of analytical challenges and pain points that needed to be addressed to ensure the successful development and manufacture of these modern biopharmaceutical medicines. Spectroscopy has and does play a hugely important role in the biopharmaceutical value chain from development to the manufacture and the quality assurance and control of these medicines. This symposium will provide an insight into how FT-IR, 2D Fluorescence (A-TEEM), Raman and Coherent Raman Spectroscopy can solve the challenges of development and monitoring of the manufacturing process of these novel medicines. As is perhaps appropriate with the critical role that the north east of the USA played in the COVID crisis, all four speakers in this symposium will come from this area, three from the Boston area and one from New Jersey. Topics will range from:

1. The use of Raman spectroscopy for high throughput screening of biopharma molecules and precursors
2. Applying 2D fluorescence for process optimization throughout the biopharmaceutical manufacturing process
3. Screening of falsified biologic drug products using fluorescence, Raman and FT-IR spectroscopy
4. Rapid ultrasensitive label-free imaging of drug delivery using coherent Raman spectroscopy

The use of spectroscopy by the pharmaceutical industry is evolving rapidly and much of the innovation behind this evolution is being driven in the north east. In this symposium we will review the use of spectroscopy to study and monitor critical biopharmaceutical materials such as mRNA, monoclonal antibodies, lipid nanoparticles, extracellular vesicles and Adeno-associated viruses (AAV's).