Analysis of Vaccine Antigens, Adjuvants, and Delivery Systems with Multi-Angle Light Scattering

Vaccines play a critical role in the prevention of several diseases worldwide, and investment in vaccine development has increased on next generation technology and strategy. Vaccines have grown in complexity, sometimes requiring novel delivery systems and adjuvants. Based on this ever-growing complexity, analytical methods for analysis must adapt. In this session we will cover advancements in analytical strategy and methods for characterizing vaccine antigens, delivery systems (e.g. lipid nanoparticles), and adjuvants. The diversity in vaccines will be highlighted, including methods for characterizing new antigen strategies and next generation tools for gaining deeper understanding of existing products. The session will have a particular focus on analysis using multi-angle light scattering, which is an information rich detection method to understand macromolecules and particles. Principals covered in this session will be applicable to pharmaceuticals beyond vaccines, including antibody-drug conjugates and RNA therapeutics.