High-Throughput and High-Resolution Mass Spectrometry for Drug Discovery and Clinical Research
Saturday, March 1, 2025 8:30 AM to 12:30 PM · 4 hr. (America/New_York)
Short Course Office - Room 153A
Short Course
Bioanalytical & Life Science
Information
High-resolution, accurate-mass (HRAM) Orbitrap mass spectrometry (MS) has transitioned from a research powerhouse to an essential tool in pharmaceutical and clinical laboratories. This short course will empower you to harness the full potential of HRAM Orbitrap MS through a dynamic blend of interactive animation and informative visualizations designed to enhance your understanding of key concepts. Learn how this technology delivers new strategies to improve sensitivity, selectivity, and data confidence for applications ranging from drug discovery and biomarker identification to diagnostics and clinical research. Gain a clear understanding of the underlying principles, practical tips for method development, optimization, and troubleshooting. Whether you're new to HRAM MS or looking to refine your expertise, this course will equip you with the knowledge and skills to drive innovation and success in your laboratory.
Day of Week
Saturday
Session Number
SC-4868
Application
Instrumentation
Methodology
Liquid Chromatography/LCMS
Primary Focus
Methodology
Short Course Information
Course Level
Intermediate
Duration
Half Day Course
Learning Objective
In this course, we will introduce an overview of common HRAM Orbitrap MS approaches, and some advanced HRAM data acquisition techniques. We will include practical strategies on how to increase throughput and leverage HRAM for optimized performance, enhanced sensitivity, selectivity, accuracy, and resolution. In addition, good practices and troubleshooting tips will be discussed.
Course Outline
Part One: Strengthen Conceptual Understanding Through Immersive Animations and Informative Visualizations
1. Full Scan
2. Full MS/AIF
3. Targeted-SIM
4. Full MS/dd-MS2
5. Full MS/AIF NL/dd-MS2
6. PRM or Targeted-MS2
7. Precursor Exclusion list
8. AcquireX
9. DIA
10. SureQuant Targeted Quantitation
11. BoxCar
12. TMT SPS MS3 with Real-Time Search
13. EThcD and ETciD
14. FAIMS
15. Charge Detection Mass Spectrometry
Part Two: Exploring How HRAM MS Solves Complex Analytical Challenges Through Case Studies
1. Targeted absolute therapeutic protein quantification: IGF-1
2. Microbiome, metaproteomic, and in-house bioinformatic solutions
3. Protein-drug characterization
Part Three: Become a Pro at Diagnosing and Resolving HRAM MS Challenges
1. Leverage the Rules Wizard for routine troubleshooting
2. Common problems in LC and their potential solutions
3. Common problems in MS and their potential solutions
Target Audience
The objective of this short course is for researchers to recognize the advantages of orbitrap-based HRAM technology. Scientists who would like to sharpen their skills of HRAM MS method development and troubleshooting.
Early Fee (before Jan 29, 2026)
$450.00
Full Fee (after Jan 29, 2026)
$550.00
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